N-Methyl-N-(trimethylsilyl)trifluoracetamid Silylierungsreagenz, zur GC-Derivatisierung

Lieferant: MACHEREY-NAGEL
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Synonyme: N-Methyl-N-(trimethylsilyl)-2,2,2-trifluoracetamidMSTFA

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N-Methyl-N-(trimethylsilyl)trifluoracetamid Silylierungsreagenz, zur GC-Derivatisierung
N-Methyl-N-(trimethylsilyl)trifluoracetamid

Silylation in GC stands for replacement of active hydrogen atoms by a trimethylsilyl group (TMS derivative).


  • Silylation can be applied on many compounds
  • Silylation reagents are easily prepared
  • MSTFA induces complete reaction with high rates
  • By-product of the reaction (N-methyltrifluoroacetamide) features high volatility and short retention time


MSTFA is the most volatile trimethylsilyl amide. The silylation reagent is a very strong TMS donor which does not cause any noticeable FID contamination even after long-time measuring series.
It is one of the most important derivatisation reagent. It can be used, to silylate hydrochloride salts of amines or amino acids directly. The already good solution characteristics can be improved by adding submolar quantities of protic solvents (e.g., TFA for extremely polar compounds such as hydrochlorides) or pyridine (e.g., for carbohydrates).

Formel: C₆H₁₂F₃NOSi
Molecular Weight: 199,25 g/mol
Siedepunkt: 70 °C (75 mm Hg)
Dichte: 1,11 g/cm³ (d20°/4°)
MDL: MFCD00000411
CAS-Nummer: 24589-78-4
EINECS: 246-331-6
UN: 2924
ADR: 3,III

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