Anti-NFKBIB Rabbit Polyclonal Antibody

Lieferant: ProSci
PRSI49-456EA 505 EUR
PRSI49-456
Anti-NFKBIB Rabbit Polyclonal Antibody
NFκB was originally identified as a factor that binds to the immunoglobulin kappa light chain enhancer in B cells. It was subsequently found in non-B cells in an inactive cytoplasmic form consisting of NFκB bound to IkB. NFκB was originally identified as a heterodimeric DNA binding protein complex consisting of p65 (RelA) and p50 (NFκB1) subunits. Other identified subunits include p52 (NFκB2), c-Rel, and RelB. The p65, cRel, and RelB subunits are responsible for transactivation. The p50 and p52 subunits possess DNA binding activity but limited ability to transactivate. p52 has been reported to form transcriptionally active heterodimers with the NFκB subunit p65, similar to p50/p65 heterodimers. The heterodimers of p52/p65 and p50/p65 are regulated by physical inactivation in the cytoplasm by IkB-a. IkB-a binds to the p65 subunit, preventing nuclear localization and DNA binding. Low levels of p52 and p50 homodimers can also exist in cells.

NFKBIB antibody can be used in immunohistochemistry starting at 10 μg/mL.

Delipidation and Defibrination

Store NFKBIB antibody at -20 °C or below prior to opening. Dilute only prior to immediate use. Aliquot contents and freeze at -20 °C or below. As with all antibodies avoid freeze/thaw cycles.

Type:
Antigen: NFKBIB
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype:
Reactivity: Human, Mouse, Rat
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