Anti-HMGA1 Rabbit Polyclonal Antibody

Lieferant: ProSci
PRSI49-286EA 480 EUR
Anti-HMGA1 Rabbit Polyclonal Antibody
HMGA1, an 11 kDa basic, DNA-binding non-histone nuclear protein, is a key member of HMGA protein family. It consists of a highly conserved AT-hook DNA-binding domain that mediates binding to AT-rich sequences in the minor groove of chromosomal DNA. It functions as architectural chromatin-binding transcription factor altering the conformation of DNA by modulating nuclear protein-DNA complexes. It is involved in many cellular processes including growth regulation, viral induction of beta-IFN gene and regulation of inducible gene transcription. It also physically interacts with transcription factors such as AP-1, Sp-1 and CAAT/enhancer binding protein-beta to modulate their ability to activate gene expression. It functions as a direct transcriptional target of c-Jun and c-Myc and is maximally expressed during embryonic development. Pathological role of HMGA1 include integration of retroviruses into chromosomes and enhancing metastasis of tumor cells.

HMGA1 antibody can be used in ELISA, Western Blot, immunohistochemistry starting at 5 μg/mL, and immunofluorescence starting at 10 μg/mL.

PBS, 0.05% BSA, 0.05% sodium azide.

PBS, 0.05% BSA, 0.05% sodium azide.

Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Antigen: HMGA1
Clonality: Polyclonal
Conjugation: Unconjugated
Host: Rabbit
Reactivity: Bat, Dog, Gibbon, Gorilla, Hamster, Horse, Human, Monkey, Mouse, Pig, Rabbit, Rat

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