Anti-HDAC4 Rabbit Polyclonal Antibody

Lieferant: ProSci
PRSI49-282EA 480 EUR
PRSI49-282
Anti-HDAC4 Rabbit Polyclonal Antibody
Antikörper
Histone deacetylase (HDAC) and histone acetyltransferase (HAT) are enzymes that regulate transcription by selectively deacetylating or acetylating the eta-amino groups of lysines located near the amino termini of core histone proteins. Eight members of HDAC family have been identified in the past several years. These HDAC family members are divided into two classes, I and II. Class I of the HDAC family comprises four members, HDAC-1, 2, 3, and 8, each of which contains a deacetylase domain exhibiting from 45 to 93% identity in amino acid sequence. Class II of the HDAC family comprises HDAC-4, 5, 6, and 7, the molecular weights of which are all about twofold larger than those of the class I members, and the deacetylase domains are present within the C-terminal regions, except that HDAC-6 contains two copies of the domain, one within each of the N-terminal and C-terminal regions. Human HDAC-1, 2 and 3 were expressed in various tissues, but the others (HDAC-4, 5, 6, and 7) showed tissue-specific expression patterns. These results suggested that each member of the HDAC family exhibits a different, individual substrate specificity and function in vivo.

Histone Deacetylase 4 antibody can be used in immunohistochemistry starting at 10 μg/mL.

Protein G Column

PBS containing 0.05% BSA and 0.05% sodium azide

Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Type:
Antigen: HDAC4
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse
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