Apurinic/apyrimidinic (AP) sites occur frequently in DNA by spontaneous hydrolysis, DNA damaging agents or DNA glycosylases that remove specific abnormal bases. ClassII AP endonucleases act to repair this damage by cleaving the phosphodiester backbone. It is primarily located in the nucleus but is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair (BER).
APEX Nuclease antibody can be used in ELISA, Western Blot, immunohistochemistry starting at 5 μg/mL, and immunofluorescence starting at 10 μg/mL.
Protein G Column
PBS, 0.02% sodium azide.
Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
Reactivity: Bovine, Dog, Gorilla, Human, Monkey, Pig, Rabbit