Anti-MYOG Mouse Monoclonal Antibody

Lieferant: ProSci
PRSI49-222EA 480 EUR
Anti-MYOG Mouse Monoclonal Antibody
Myogenin is a member of the MyoD family of myogenic basic helix-loop-helix (bHLH) transcription factors that also includes MyoD, Myf-5, and MRF4 (also known as herculinor Myf-6). MyoD family members are expressed exclusively in skeletal muscle and play a key role in activating myogenesis by binding to enhancer sequences of muscle-specific genes. The regulatory domain of MyoD is approximately 70 amino acids in length and includes both a basic DNA binding motif and a bHLH dimerization motif. MyoD family members share about 80% amino acid homology in their bHLH motifs. Transfection of myogenin and other family members into a variety of non-muscle cells has been shown to either convert these cells to myogenic cells, or to transcriptionally activate a set of otherwise unexpressed muscle-specific genes. In addition to activating muscle specific genes, members of the MyoD family members activate their own transcription and transactivate the transcription of other MyoD family members. Each member of the MyoD family has distinct roles in muscle development; myogenin plays a key role in muscle maturation. Myogenin migrates at a molecular weight of ~34 kDa by SDS-PAGE. Myogenin, also known as Myf-4, is a muscle specific transcription factor that converts multipotential mesodermal cells to myoblasts and is essential for the development of functional skeletal muscle. It is a member of the basic helix-loop-helix gene family.

Myogenin antibody can be used in immunohistochemistry starting at 10 μg/mL, and immunohistochemistry in frozen tissues starting at 1:50.

Protein G Column

PBS, 0.05% BSA, 0.05% sodium azide.

Aliquot and store at -80°C. Avoid multiple freeze-thaw cycles.

Antigen: MYOG
Clonality: Monoclonal
Conjugation: Unconjugated
Host: Mouse
Isotype: IgG
Reactivity: Human, Mouse, Rat

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