MKK4, a MAP2K type protein kinase, is a member of the stress-activated protein kinase (SAPK) pathways which convey pro-apoptotic signals. MKK4 is activated by MEKK1 or MEKK2, and to a lesser extent by GCK or ASK1. MKK4 phosphorylates and activates JNK1, JNK2 and p38. MKK4 deficiency in mouse embryos led to lethality after embryonic day 12.5 and was associated with abnormal liver development. Additional studies have linked MKK4 to tumor suppression.
MAP2K4 antibody can be used in ELISA, and immunohistochemistry starting at 5 μg/mL.
PBS, 0.02% sodium azide, 50% glycerol.
Aliquot and store at -80°C. Avoid multiple freeze-thaw cycles.
Reactivity: Human, Mouse, Rat