Anti-TP53BP1 Rabbit Polyclonal Antibody

Lieferant: ProSci
PRSI48-864EA 480 EUR
PRSI48-864
Anti-TP53BP1 Rabbit Polyclonal Antibody
Antikörper
P53-binding protein 1 (53BP1) plays a critical role in tumor suppression and is a putative substrate of ATM kinase. Upon DNA damage, it is phosphorylated and relocalizes to the presumptive sites of damage, specifically, double-strand breaks. This also suggests a role in DNA repair, maintaining genomic stability. Tumor protein p53 binding protein 1 binds to the central domain of p53 required for site-specific DNA binding thus inhibiting the ability of p53 to bind DNA. TP53BP1 also functions as a checkpoint protein with properties of a DNA double-strand break sensor. It is a putative substrate of ATM kinase and is phosphorylated in response to DNA damage and localizes to sites of double-strand breaks.

TP53BP1 antibody can be used in ELISA, and immunohistochemistry starting at 5 μg/mL.

Affinity Chromatography

PBS, pH 7.2, no preservatives added.

Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Type:
Antigen: TP53BP1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human
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