JAB-1 is a 38 kDa protein which was originally described as a coactivator for cJUN. It is present in a large protein complex called the """"Signalosome"""", which has been proposed to play a signaling role in mammalian cells. This protein complex appears to be analogous to the COP9 complex in plants, which is important in light-mediated plant development. Although the specific function of JAB-1 in this complex is unclear, it has recently been implicated in targeting proteins for degradation by the proteasome.
COPS5 antibody can be used in Western Blot starting at 1 - 2 μg/mL, and immunohistochemistry starting at 10 μg/mL.
Protein G Column
PBS, pH 7.4
Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.