ERK2, a MAPK type protein kinase, is a member of the Ras MAPK pathway. This pathway modulates the activity of transcription factors, structural proteins and other protein kinases, leading to biological responses such as cell proliferation and differentiation. Inactive ERK2 associates with MAPK/ERK kinases (MEK) 1 and 2 in the cytosol. Upon stimulation, MEK1/2 phosphorylates and activates ERK2 causing dissociation of the MEK/ERK complex. A portion of the activated ERK2 pool forms dimers and translocates to the nucleus to activate nuclear proteins, such as ELK-1 and MSK1. Cytosolic ERK 2 acts on a different set of substrates, including MNK1/2 and MAPKAP-K1.
MAPK1 antibody can be used in immunohistochemistry starting at 10 μg/mL, immunoprecipitation, and flow cytometry.
Phosphate-buffered solution, pH 7.2, 0.09% sodium azide, 50% glycerol, 0.1% gelatin.
Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
Reactivity: Human, Mouse, Rat