Anti-AKT1 Rabbit Polyclonal Antibody

Lieferant: ProSci
PRSI48-500EA 375 EUR
Anti-AKT1 Rabbit Polyclonal Antibody
AKT1 encodes a RAC/AKT-type protein kinase that contains a N-terminal pleckstrin-homology (PH) domain and a central catalytic domain closely related to both cAMP-dependent protein kinase and protein kinase C. The protein is a member of PI3K-mediated signaling pathways associated with the regulation of proliferation, survival, protein synthesis, and metabolism. It is phosphorylated by 3'-phosphoinositide-dependent kinase-1 (PDK1) in response to stimulation by growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), and insulin. Activated AKT1 has been shown to phosphorylate and inactivate components of the apoptotic machinery. AKT1 (-/-) mice have been shown to be viable but smaller than wild-type littermates, and they have a reduced lifespan and increased spontaneous apoptosis in several tissues when exposed to stressors. AKT1 protein is the cellular homolog of the product of the retroviral oncogene v-akt, and has been implicated in numerous cancers.

AKT1 antibody can be used in ELISA, Western Blot, immunohistochemistry starting at 5 μg/mL, immunofluorescence starting at 10 μg/mL, and immunoprecipitation.

PBS, 0.02% sodium azide, 50% glycerol.

Aliquot and store at -80°C. Avoid multiple freeze-thaw cycles.

Antigen: AKT1
Clonality: Polyclonal
Conjugation: Unconjugated
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat

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