KIT encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. KIT is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Somatic gain-of-function mutations in the extracellular domain, kinase domains 1 and 2 are found in gastrointestinal stromal tumors (GISTs). Mutations in c-KIT gene are also associated with mast cell disease, acute myelogenous lukemia, and piebaldism. Tyrosine kinase inhibitor STI571 has been shown to inhibit GIST cells that express mutated c-KIT.
KIT Oncogene antibody can be used in ELISA starting at 1:10000, Western Blot starting at 1:500 - 1:2000, and immunohistochemistry starting at 1:200 - 1:400.
PBS, 0.1% sodium azide.
Aliquot and store at -80°C. Avoid multiple freeze-thaw cycles.
Reactivity: Bat, Bovine, Dog, Gibbon, Goat, Gorilla, Horse, Human, Monkey, Pig, Rabbit