Group I of the Metabotropic Glutamate Receptors includes GRM1 and GRM5, receptors that have been shown to activate phospholipase C. Alternative splice variants of GRM5 have been described, but their full-length nature has not been determined. Inflammation results in the activation of mGluR1 and mGluR5 in dorsal horn neurons of the spinal cord, leading to extracellular signal-regulated kinase (ERK) activation, which is required for nociceptive plasticity and enhanced pain. GRM5 is involved in inflammatory mechanical hyperalgesia and potentially in schizophrenia
GRM5 antibody can be used in Western Blot starting at 1:100, and immunohistochemistry starting at 1:100.
PBS, 0.1% sodium azide.
PBS, 0.1% sodium azide.
Aliquot and store at -80°C. Avoid multiple freeze-thaw cycles.
Type:
Antigen: GRM5
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype:
Reactivity: Bat, Gibbon, Bovine, Chicken, Dog, Hamster, Horse, Human, Monkey, Mouse, Pig, Rabbit, Rat