GPR44, also called CRTH2, is a Prostanoid Receptor that binds prostaglandin D2. PGD2 signals through CRTH2 to induce Th2, eosinophil, and basophil chemotaxis in a G-alpha(i) dependent manner. CRTH2 may play a role in mast cell-mediated immune responses such as those involved in allergic reactions. This receptor is upregulated in activated T helper-2 (Th2) cells, peripheral blood basophils, and eosinophils, but not in Th1 lineage cells. It may be a useful marker for Th2 and Tc2 cells.
GPR44 antibody can be used in immunohistochemistry starting at 10 μg/mL.
PBS, 0.1% sodium azide.
Aliquot and store at -20°C. Avoid multiple freeze-thaw cycles.
Reactivity: Gorilla, Human