CCR3, a Chemokine Receptor, was cloned from human eosinophils (Daugherty et al., 1996). This receptor binds specifically the chemokine eotaxin and activates eosinophil leukocytes. CCR3 also responds to a variety of beta-chemokines (CC motif) including RANTES, monocyte chemotactic proteins, and mucosae-associated epithelial chemokine (MEC). CCR3 is a key mediator of allergic reactions; activation of this receptor stimulates the production of interleukins required for activation of basophils and eosinophils (Sallusto et al., 1997). CCR3 plays a role in the progression and pathogenesis of inflammatory diseases such as asthma, multiple sclerosis, and Alzheimer's disease. This receptor also facilitates HIV-1 penetration in heart and brain.
CCR3 antibody can be used in ELISA, and immunohistochemistry starting at 20 μg/mL.
PBS, 0.1% sodium azide.
Aliquot and store at -20°C. Avoid multiple freeze-thaw cycles.