RIM2 Antibody: Rab3-interacting molecules (RIMs) are synaptic proteins necessary for neuronal transmission and plasticity. RIM1 and RIM2 proteins are expressed in overlapping but distinct patterns throughout the brain. While the ablation of either gene was not lethal in mice, the deletion of both resulted in postnatal mortality. This lethality is due to a defect in neurotransmitter release; synapses without RIM proteins can still release neurotransmitters but are unable to do so in response to normal Ca2+ triggers. Like RIM1, RIM2 is thought to be an effector protein for Rab3, binding to Rab3 on synaptic vesicles in a GTP-dependent manner.
RIM2 antibody can be used for detection of RIM2 by immunohistochemistry at 5 μg/mL.
RIM2 Antibody is affinity chromatography purified via peptide column.
RIM2 Antibody is supplied in PBS containing 0.02% sodium azide.
RIM2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.