TBC1D4 Antibody: TBC1D4, also known as the Akt substrate AS160, was initially identified as an Akt substrate containing a GTPase-activating domain that regulates GLUT4 trafficking, with activation following insulin stimulation. TBC1D4 truncations in humans is a major cause of dominant inherited insulin resistance. The loss of TBC1D4 results in the accumulation of GLUT4 in compartments that are primed for fusion in basal adipocytes.
TBC1D4 antibody can be used for immunohistochemistry starting at 10 μg/mL.
TBC1D4 Antibody is affinity chromatography purified via peptide column.
TBC1D4 Antibody is supplied in PBS containing 0.02% sodium azide.
TBC1D4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.